Multimodal assessment of right ventricle overload-metabolic and clinical consequences in pulmonary arterial hypertension.

ABSTRACT:

Background

In pulmonary arterial hypertension (PAH) increased afterload leads to adaptive processes of the right ventricle (RV) that help to maintain arterio-ventricular coupling of RV and preserve cardiac output, but with time the adaptive mechanisms fail. In this study, we propose a multimodal approach which allows to estimate prognostic value of RV coupling parameters in PAH patients.

Methods

Twenty-seven stable PAH patients (49.5 ± 15.5 years) and 12 controls underwent cardiovascular magnetic resonance (CMR). CMR feature tracking analysis was performed for RV global longitudinal strain assessment (RV GLS). RV-arterial coupling was evaluated by combination of RV GLS and three proposed surrogates of RV afterload-pulmonary artery systolic pressure (PASP), pulmonary vascular

SUBMITTER: Kazimierczyk R 

PROVIDER: S-EPMC8108462 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature