Ontology highlight
ABSTRACT:
SUBMITTER: Turn RE
PROVIDER: S-EPMC8108518 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Turn Rachel E RE Linnert Joshua J Gigante Eduardo D ED Wolfrum Uwe U Caspary Tamara T Kahn Richard A RA
Molecular biology of the cell 20210217 8
ELMOD2 is a GTPase-activating protein with uniquely broad specificity for ARF family GTPases. We previously showed that it acts with ARL2 in mitochondrial fusion and microtubule stability and with ARF6 during cytokinesis. Mouse embryonic fibroblasts deleted for ELMOD2 also displayed changes in cilia-related processes including increased ciliation, multiciliation, ciliary morphology, ciliary signaling, centrin accumulation inside cilia, and loss of rootlets at centrosomes with loss of centrosome ...[more]