Memory precision of object-location binding is unimpaired in APOE ε4-carriers with spatial navigation deficits.

ABSTRACT: Research suggests that tests of memory fidelity, feature binding and spatial navigation are promising for early detection of subtle behavioural changes related to Alzheimer's disease. In the absence of longitudinal data, one way of testing the early detection potential of cognitive tasks is through the comparison of individuals at different genetic risk for Alzheimer's dementia. Most studies have done so using samples aged 70 years or older. Here, we tested whether memory fidelity of long-term object-location binding may be a sensitive marker even among cognitively healthy individuals in their mid-60s by comparing participants at low and higher risk based on presence of the ε4-allele of the apolipoprotein gene (n = 26 ε3ε3, n = 20 ε3ε4 carriers). We used a conti

SUBMITTER: Gellersen HM 

PROVIDER: S-EPMC8108563 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature