Plasma Metabolomic Signatures of Chronic Obstructive Pulmonary Disease and the Impact of Genetic Variants on Phenotype-Driven Modules.

ABSTRACT: Background: Small studies have recently suggested that there are specific plasma metabolic signatures in chronic obstructive pulmonary disease (COPD), but there have been no large comprehensive study of metabolomic signatures in COPD that also integrate genetic variants. Materials and Methods: Fresh frozen plasma from 957 non-Hispanic white subjects in COPDGene was used to quantify 995 metabolites with Metabolon's global metabolomics platform. Metabolite associations with five COPD phenotypes (chronic bronchitis, exacerbation frequency, percent emphysema, post-bronchodilator forced expiratory volume at one second [FEV₁]/forced vital capacity [FVC], and FEV₁ percent predicted) were assessed. A metabolome-wide association study was performed to find geneti

SUBMITTER: Gillenwater LA 

PROVIDER: S-EPMC8109053 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature