High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes.

ABSTRACT: The aim of the present study was to evaluate the involvement of CD52 in adipocytes as well as to explore its effect on type 2 diabetes mellitus (T2DM), and to improve our understanding of the potential molecular events of obesity with type 2 diabetes. Global changes in the CD52 expression patterns were detected in adipocytes and preadipocytes derived from obese and lean individuals. In particular, CD52 was identified as significantly differentially upregulated and was analyzed, both in vitro and in vivo, using various approaches. In vitro experiments, CD52 was a significantly up-regulated mRNA in mature adipocytes and preadipocytes. In addition, CD52 gradually increased with the differentiation of preadipocytes. In vivo experiments, the expression of CD52 in hig

SUBMITTER: Mao R 

PROVIDER: S-EPMC8109061 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature