Translational control of gene expression by eIF2 modulates proteostasis and extends lifespan.

ABSTRACT: Although the stress response in eukaryotes depends on early events triggered in cells by environmental insults, long-term processes such as aging are also affected. The loss of cellular proteostasis greatly impacts aging, which is regulated by the balancing of protein synthesis and degradation systems. As translation is the input event in proteostasis, we decided to study the role of translational activity on cell lifespan. Our hypothesis was that a reduction on translational activity or specific changes in translation may increase cellular longevity. Using mutant strains of Schizosaccharomyces pombe and various stress conditions, we showed that translational reduction caused by phosphorylation of eukaryotic translation initiation factor 2 (eIF2) during the exponential growth phase

SUBMITTER: Jimenez-Saucedo T 

PROVIDER: S-EPMC8109070 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature