Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip.

ABSTRACT:

Background

Developmental dysplasia of the hip (DDH) is the most common joint disease in child orthopedics. Secreted Frizzled-Related Protein 3 (FRZB) plays an important role in joint development. however, no direct association between FRZB and DDH has been demonstrated.

Methods

Analysis of genotype distribution and allele frequency for detected single nucleotide polymorphisms (SNP) of FRZB was performed. FRZB expression was assayed in DDH joint tissues. Further experiments to identify the chondrogenic properties of FRZB were conducted. Potential upstream miRNAs for FRZB were assayed in DDH.

Results

Significant difference in genotype distribution for rs3768842 (OR=1.46, P=0.0081) and rs2242040 (OR=0.65, P=0.0067) was found. DDH joint

SUBMITTER: Xu R 

PROVIDER: S-EPMC8109121 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature