Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: Prospective cohort study.

ABSTRACT:

Objective

To investigate maternal immunoglobulins' (IgM, IgG) response to SARS-CoV-2 infection during pregnancy and IgG transplacental transfer, to characterize neonatal antibody response to SARS-CoV-2 infection, and to longitudinally follow actively- and passively-acquired SARS-CoV-2 antibodies in infants.

Design

A prospective observational study.

Setting

A public healthcare system in Santa Clara County (CA, USA).

Participants

Women with SARS-CoV-2 infection during pregnancy and their infants were enrolled between April 15, 2020 and March 31, 2021.

Outcomes

SARS-CoV-2 serology analyses in the cord and maternal blood at delivery and longitudinally in infant blood between birth and 28 weeks of life.

Results

Of 145 mothers who tested positive for SA

SUBMITTER: Song D 

PROVIDER: S-EPMC8109203 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature