SARS -CoV-2 T-cell immunity to variants of concern following vaccination.

ABSTRACT: Recently, two mRNA vaccines to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become available, but there is also an emergence of SARS-CoV-2 variants with increased transmissibility and virulence^1-6. A major concern is whether the available vaccines will be equally effective against these variants. The vaccines are designed to induce an immune response against the SARS-CoV-2 spike protein^7,8, which is required for viral entry to host cells⁹. Immunity to SARS-CoV-2 is often evaluated by antibody production, while less is known about the T-cell response. Here we developed, characterized, and implemented two standardized, functional assays to measure T-cell immunity to SARS-CoV-2 in uninfected, convalescent, and vaccinated individuals. We fo

SUBMITTER: Gallagher KME 

PROVIDER: S-EPMC8109204 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature