Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes.

ABSTRACT: During development, two cell types born from closely related progenitor pools often express identical transcriptional regulators despite their completely distinct characteristics. This phenomenon implies the need for a mechanism that operates to segregate the identities of the two cell types throughout differentiation after initial fate commitment. To understand this mechanism, we investigated the fate specification of spinal V2a interneurons, which share important developmental genes with motor neurons (MNs). We demonstrate that the paired homeodomain factor Chx10 functions as a critical determinant for V2a fate and is required to consolidate V2a identity in postmitotic neurons. Chx10 actively promotes V2a fate, downstream of the LIM-homeodomain factor Lhx3, while concomitantly suppressin

SUBMITTER: Clovis YM 

PROVIDER: S-EPMC8109239 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature