Emergence of oxacillinase-181 carbapenemase-producing diarrheagenic Escherichia coli in Ghana.

ABSTRACT: The emergence and spread of carbapenemase-producing bacteria are serious threats to public health. We characterized two OXA-181-producing Escherichia coli isolates from pediatric patients with diarrhea from Ghana. bla_OXA-₁₈₁ was localized on the self-conjugative IncX3-containing plasmid in the E. coli ST410 isolate, belonging to an emerging lineage, and an IncFIC(FII)-containing plasmid in E. coli ST940. The bla_OXA-181-qnrS1 region was found on the IS26 composite transposon, which contained a 366-bp deletion in the region encoding the Rep A protein for the IncX3-containing plasmid. The IncFIC(FII) plasmid was novel and integrated with an approximately 39-kb IncX1 plasmid through conjugal transfer. Both plasmi

SUBMITTER: Prah I 

PROVIDER: S-EPMC8110189 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature