GABA_A presynaptic inhibition regulates the gain and kinetics of retinal output neurons.

ABSTRACT: Output signals of neural circuits, including the retina, are shaped by a combination of excitatory and inhibitory signals. Inhibitory signals can act presynaptically on axon terminals to control neurotransmitter release and regulate circuit function. However, it has been difficult to study the role of presynaptic inhibition in most neural circuits due to lack of cell type-specific and receptor type-specific perturbations. In this study, we used a transgenic approach to selectively eliminate GABA_A inhibitory receptors from select types of second-order neurons - bipolar cells - in mouse retina and examined how this affects the light response properties of the well-characterized ON alpha ganglion cell retinal circuit. Selective loss of GABA_A receptor-mediated presynaptic

SUBMITTER: Nagy J 

PROVIDER: S-EPMC8110304 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature