Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population.

ABSTRACT: Dendritic cells residing in the skin represent a large family of antigen-presenting cells, ranging from long-lived Langerhans cells (LC) in the epidermis to various distinct classical dendritic cell subsets in the dermis. Through genetic fate mapping analysis and single-cell RNA-sequencing, we have identified a novel separate population of LC-independent CD207⁺CD326⁺ LC^like cells in the dermis that homed at a slow rate to the lymph nodes (LNs). These LC^like cells are long-lived and radio-resistant but, unlike LCs, they are gradually replenished by bone marrow-derived precursors under steady state. LC^like cells together with cDC1s are the main migratory CD207⁺CD326⁺ cell fractions present in the LN and not, as curr

SUBMITTER: Sheng J 

PROVIDER: S-EPMC8110305 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature