Dataset Information

Association of PM_2.5 exposure with hospitalization for cardiovascular disease in elderly individuals in Japan.

ABSTRACT: Although exposure to particulate matter with aerodynamic diameters ≤ 2.5 µm (PM_2.5) influences cardiovascular disease (CVD), its association with CVD-related hospitalizations of super-aged patients in Japan remains uncertain. We investigated the relationship between short-term PM_2.5 exposure and CVD-related hospitalizations, lengths of hospital stays, and medical expenses. We analyzed the Japanese national database of patients with CVD (835,405) admitted to acute-care hospitals between 2012 and 2014. Patients with planned hospitalizations and those with missing PM_2.5 exposure data were excluded. We classified the included patients into five quintiles based on their PM_2.5 exposure: PM-5, -4, -3, -2, and -1 groups, in descending order of concentration. Compared with the PM-1 group, the other groups had higher hospitalization rates. The PM-3, -4, and -5 groups exhibited increased hospitalization durations and medical expenses, compared with the PM-1 group. Interestingly, the hospitalization period was longer for the ≥ 90-year-old group than for the ≤ 64-year-old group, yet the medical expenses were lower for the former group. Short-term PM_2.5 exposure is associated with increased CVD-related hospitalizations, hospitalization durations, and medical expenses. The effects of incident CVDs were more marked in elderly than in younger patients. National PM_2.5 concentrations should be reduced and the public should be aware of the risks.

SUBMITTER: Kaihara T

PROVIDER: S-EPMC8110517 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Association of PM2.5 exposure with hospitalization for cardiovascular disease in elderly individuals in Japan.

Kaihara Toshiki T Yoneyama Kihei K Nakai Michikazu M Higuma Takumi T Sumita Yoko Y Miyamoto Yoshihiro Y Watanabe Mika M Izumo Masaki M Ishibashi Yuki Y Tanabe Yasuhiro Y Harada Tomoo T Yasuda Satoshi S Ogawa Hisao H Akashi Yoshihiro J YJ

Scientific reports 20210510 1

Although exposure to particulate matter with aerodynamic diameters ≤ 2.5 µm (PM2.5) influences cardiovascular disease (CVD), its association with CVD-related hospitalizations of super-aged patients in Japan remains uncertain. We investigated the relationship between short-term PM2.5 exposure and CVD-related hospitalizations, lengths of hospital stays, and medical expenses. We analyzed the Japanese national database of patients with CVD (835,405) admitted to acute-care hospi ...[more]

PMID: 33972608

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Project description:Epidemiologic studies have found associations between fine particulate matter (PM2.5) exposure and adverse health effects using exposure models that incorporate monitoring data and other relevant information. Here, we use nine PM2.5 concentration models (i.e., exposure models) that span a wide range of methods to investigate i) PM2.5 concentrations in 2011, ii) potential changes in PM2.5 concentrations between 2011 and 2028 due to on-the-books regulations, and iii) PM2.5 exposure for the U.S. population and four racial/ethnic groups. The exposure models included two geophysical chemical transport models (CTMs), two interpolation methods, a satellite-derived aerosol optical depth-based method, a Bayesian statistical regression model, and three data-rich machine learning methods. We focused on annual predictions that were regridded to 12-km resolution over the conterminous U.S., but also considered 1-km predictions in sensitivity analyses. The exposure models predicted broadly consistent PM2.5 concentrations, with relatively high concentrations on average over the eastern U.S. and greater variability in the western U.S. However, differences in national concentration distributions (median standard deviation: 1.00 μg m-3) and spatial distributions over urban areas were evident. Further exploration of these differences and their implications for specific applications would be valuable. PM2.5 concentrations were estimated to decrease by about 1 μg m-3 on average due to modeled emission changes between 2011 and 2028, with decreases of more than 3 μg m-3 in areas with relatively high 2011 concentrations that were projected to experience relatively large emission reductions. Agreement among models was closer for population-weighted than uniformly weighted averages across the domain. About 50% of the population was estimated to experience PM2.5 concentrations less than 10 μg m-3 in 2011 and PM2.5 improvements of about 2 μg m-3 due to modeled emission changes between 2011 and 2028. Two inequality metrics were used to characterize differences in exposure among the four racial/ethnic groups. The metrics generally yielded consistent information and suggest that the modeled emission reductions between 2011 and 2028 would reduce absolute exposure inequality on average.

Dataset Information

Association of PM_2.5 exposure with hospitalization for cardiovascular disease in elderly individuals in Japan.

Publications

Association of PM<sub>2.5</sub> exposure with hospitalization for cardiovascular disease in elderly individuals in Japan.

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