A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease.

ABSTRACT:

Background

Advanced cervical cancer carries a particularly poor prognosis, and few treatment options exist. Identification of effective molecular markers is vital to improve the individualisation of treatment. We investigated transcriptional data from cervical carcinomas related to patient survival and recurrence to identify potential molecular drivers for aggressive disease.

Methods

Primary tumour RNA-sequencing profiles from 20 patients with recurrence and 53 patients with cured disease were compared. Protein levels and prognostic impact for selected markers were identified by immunohistochemistry in a population-based patient cohort.

Results

Comparison of tumours relative to recurrence status revealed 121 differentially expressed genes. From this gene set, a 10-gen

SUBMITTER: Halle MK 

PROVIDER: S-EPMC8110544 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature