High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice.

ABSTRACT: Repeated head impact exposure can cause memory and behavioral impairments. Here, we report that exposure to non-damaging, but high frequency, head impacts can alter brain function in mice through synaptic adaptation. High frequency head impact mice develop chronic cognitive impairments in the absence of traditional brain trauma pathology, and transcriptomic profiling of mouse and human chronic traumatic encephalopathy brain reveal that synapses are strongly affected by head impact. Electrophysiological analysis shows that high frequency head impacts cause chronic modification of the AMPA/NMDA ratio in neurons that underlie the changes to cognition. To demonstrate that synaptic adaptation is caused by head impact-induced glutamate release, we pretreated mice with memantine prior to head imp

SUBMITTER: Sloley SS 

PROVIDER: S-EPMC8110563 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature