Nasal DNA methylation differentiates severe from non-severe asthma in African-American children.

ABSTRACT:

Background

Asthma is highly heterogeneous, and severity evaluation is key to asthma management. DNA methylation (DNAm) contributes to asthma pathogenesis. This study aimed to identify nasal epithelial DNAm differences between severe and nonsevere asthmatic children and evaluate the impact of environmental exposures.

Methods

Thirty-three nonsevere and 22 severe asthmatic African American children were included in an epigenome-wide association study. Genome-wide nasal epithelial DNAm and gene expression were measured. CpG sites associated with asthma severity and environmental exposures and predictive of severe asthma were identified. DNAm was correlated with gene expression. Enrichment for transcription factor (TF) binding sites or histone modifications surrounding DNAm diffe

SUBMITTER: Zhu T 

PROVIDER: S-EPMC8110596 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature