Dynamics of leukocyte telomere length in adults aged 50 and older: a longitudinal population-based cohort study.

ABSTRACT: It is well established from previous cross-sectional studies that telomeres shorten with age. However, due to a considerable inter-individual variation in telomere length (TL), its relationship with biological aging is difficult to unpick. Longitudinal repeated assessments of TL changes within individuals should augment our understanding of TL dynamics in aging. This study disentangles within- and inter-individual effects of age on leukocyte telomere length (LTL) dynamics in a large population-based cohort of older adults. A total of 4053 subjects aged 50 and older from the WHO Study on global AGEing and adult health (SAGE) in Shanghai were studied. Relative LTL (T/S ratio) was measured at baseline (2009-2010) and follow-up (2017-2018) by quantitative real-time polymerase chain reaction. W

SUBMITTER: Huang Z 

PROVIDER: S-EPMC8110630 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature