Age-related compositional changes and correlations of gut microbiome, serum metabolome, and immune factor in rats.

ABSTRACT: Aging is a complex physiological process associated with degenerative disorder of metabolism and immune function, which contributes to the occurrence of senile diseases. The gut microbiota affects systemic inflammation in aging processes probably through metabolism, but their relationship is still unclear. In this study, 16S-rRNA-sequencing technology, gas chromatography-time-of-flight mass spectrometry (GC-TOFMS)-based metabolic profiling, and immune factor analysis combined with advanced differential and association analysis were employed to investigate the correlation between the microbiome, metabolome, and immune factors in male Wistar rats across lifespan. Our findings showed significant changes in the ileum microbiome and serum metabolome compositions across aging process. A two-leve

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8110635 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature