Emerging concepts in intestinal immune control of obesity-related metabolic disease.
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ABSTRACT:
SUBMITTER: Khan S
PROVIDER: S-EPMC8110751 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Emerging concepts in intestinal immune control of obesity-related metabolic disease.
Khan Saad S Luck Helen H Winer Shawn S Winer Daniel A DA
Nature communications 20210510 1
The intestinal immune system is an important modulator of glucose homeostasis and obesity-associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites shape intestinal immunity during obesity. The intestinal immune system in turn affects processes such as intestinal permeability, immune cell trafficking, and intestinal hormone availability, impacting systemic insulin resistance. Understanding these pathways might identify mechanisms underlying treatments for in ...[more]
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