Does a high Mandard score really define a poor response to chemotherapy in oesophageal adenocarcinoma?

ABSTRACT:

Background

A high Mandard score implies a non-response to chemotherapy in oesophageal adenocarcinoma. However, some patients exhibit tumour volume reduction and a nodal response despite a high score. This study examines survival and recurrence patterns in these patients.

Methods

Clinicopathological factors were analysed using multivariable Cox regression assessing time to death and recurrence. Computed tomography-estimated tumour volume change was examined in a subgroup of consecutive patients.

Results

Five hundred and fifty-five patients were included. Median survival was 55 months (Mandard 1-3) and 21 months (Mandard 4 and 5). In the Mandard 4 and 5 group (332 patients), comparison between complete nodal responders and persistent nodal disease showed improved surviv

SUBMITTER: Knight WRC 

PROVIDER: S-EPMC8110771 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature