Tertiary lymphoid structure score: a promising approach to refine the TNM staging in resected non-small cell lung cancer.

ABSTRACT:

Background

We previously proposed an immune cell score (tumour node metastasis (TNM)-Immune cell score) classifier as an add-on to the existing TNM staging system for non-small cell lung cancer (NSCLC). Herein, we examined how to reliably assess a tertiary lymphoid structure (TLS) score to refine the TNM staging system.

Methods

Using immunohistochemistry (CD8/cytokeratin), we quantified TLS in resected NSCLC whole-tumour tissue sections with three different scoring models on two independent collections (total of 553 patients). In a pilot setting, NanoString gene expression signatures were analysed for associations with TLS.

Results

The number of TLSs significantly decreased in stage III patients as compared to stage II. The TLS score was an independent positive progno

SUBMITTER: Rakaee M 

PROVIDER: S-EPMC8110789 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature