Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue.

ABSTRACT: Disturbed shear stress is thought to be the driving factor of neointimal hyperplasia in blood vessels and grafts, for example in hemodialysis conduits. Despite the common occurrence of neointimal hyperplasia, however, the mechanistic role of shear stress is unclear. This is especially problematic in the context of in situ scaffold-guided vascular regeneration, a process strongly driven by the scaffold mechanical environment. To address this issue, we herein introduce an integrated numerical-experimental approach to reconstruct the graft-host response and interrogate the mechanoregulation in dialysis grafts. Starting from patient data, we numerically analyze the biomechanics at the vein-graft anastomosis of a hemodialysis conduit. Using this biomechanical data, we show in an in vitro vascul

SUBMITTER: van Haaften EE 

PROVIDER: S-EPMC8110791 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature