Screening and Identification of Key Microenvironment-Related Genes in Non-functioning Pituitary Adenoma.

ABSTRACT:

Purpose

Non-functioning pituitary adenoma (NFPA) is a very common type of intracranial tumor, which can be locally invasive and can have a high recurrence rate. The tumor microenvironment (TME) shows a high correlation with tumor pathogenesis and prognosis. The current study aimed to identify microenvironment-related genes in NFPAs and assess their prognostic value.

Methods

73 NFPA tumor samples were collected from Beijing Tiantan Hospital and transcriptional expression profiles were obtained through microarray analysis. The immune and stromal scores of each sample were calculated through the ESTIMATE algorithm, and the patients were divided into high and low immune/stromal score groups. Intersection differentially expressed genes (DEGs) were then obtained to construct a pro

SUBMITTER: Guo J 

PROVIDER: S-EPMC8110910 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature