Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis.

ABSTRACT:

Background

Activation of mTORC1 plays a significant role in cancer development and progression. However, the metabolic mechanisms to sustain mTORC1 activation of cancer cells within stressed environments are still under-appreciated. We recently revealed high autophagy activity in tumour cells with mTORC1 hyper-activation. Nevertheless, the functions and mechanisms of autophagy in regulating mTORC1 in glioma are not studied.

Methods

Using glioma patient database and human glioma cells, we assessed the mechanisms and function of selective autophagy to sustain mTORC1 hyper-activation in glioma.

Results

We revealed a strong association of altered mRNA levels in mTORC1 upstream and downstream genes with prognosis of glioma patients. Our results indicated that autophagy-med

SUBMITTER: Wang C 

PROVIDER: S-EPMC8110959 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature