Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in <i>Drosophila</i>.

ABSTRACT: Alpha-synuclein (α-syn) mislocalization and accumulation in intracellular inclusions is the major pathological hallmark of degenerative synucleinopathies, including Parkinson's disease, Parkinson's disease with dementia and dementia with Lewy bodies. Typical symptoms are behavioural abnormalities including motor deficits that mark disease progression, while non-motor symptoms and synaptic deficits are already apparent during the early stages of disease. Synucleinopathies have therefore been considered synaptopathies that exhibit synaptic dysfunction prior to neurodegeneration. However, the mechanisms and events underlying synaptopathy are largely unknown. Here we investigated the cascade of pathological events underlying α-syn accumulation and toxicity in a Drosophila model of synuc

SUBMITTER: Bridi JC 

PROVIDER: S-EPMC8111063 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature