Development and Validation of a Metabolic-related Prognostic Model for Hepatocellular Carcinoma.

ABSTRACT:

Background and aims

Growing evidence suggests that metabolic-related genes have a significant impact on the occurrence and development of hepatocellular carcinoma (HCC). However, the prognostic value of metabolic-related genes for HCC has not been fully revealed.

Methods

mRNA sequencing and clinical data were obtained from The Cancer Genome Atlas and the GTEx Genotype-Tissue Expression comprehensive database. Differentially expressed metabolic-related genes in tumor tissues (n=374) and normal tissues (n=160) were identified by the Wilcoxon test. Time-dependent receiver operating characteristic curve analysis, univariate multivariate Cox regression analysis and Kaplan-Meier survival analysis were used to evaluate the predictive effectiveness and independence of

SUBMITTER: Huo J 

PROVIDER: S-EPMC8111106 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature