An Immune Model to Predict Prognosis of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy Based on Support Vector Machine.

ABSTRACT: Tumor microenvironment has been increasingly proved to be crucial during the development of breast cancer. The theory about the conversion of cold and hot tumor attracted the attention to the influences of traditional therapeutic strategies on immune system. Various genetic models have been constructed, although the relation between immune system and local microenvironment still remains unclear. In this study, we tested and collected the immune index of 262 breast cancer patients before and after neoadjuvant chemotherapy. Five indexes were selected and analyzed to form the prediction model, including the ratio values between after and before neoadjuvant chemotherapy of CD4⁺/CD8⁺ T cell ratio; lymphosum of T, B, and natural killer (NK) cells; CD3⁺CD8^+</

SUBMITTER: Wang M 

PROVIDER: S-EPMC8111218 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature