Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation.

ABSTRACT: Cell signaling mechanisms modulate gene expression in response to internal and external stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription and translation processes. The post-transcriptional control of mRNA metabolism is mediated by the so-called RNA-binding proteins (RBPs), which assemble with specific transcripts forming messenger ribonucleoprotein particles of highly dynamic composition. RBPs constitute a class of trans-acting regulatory proteins with affinity for certain consensus elements present in mRNA molecules. However, these regulators are subjected to post-translational modifications (PTMs) that constantly adjust their activity to maintain cell homeostasis. PTMs can dramatically change the subcellular localization, the binding

SUBMITTER: Velazquez-Cruz A 

PROVIDER: S-EPMC8111222 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature