Conceptus metabolomic profiling reveals stage-specific phenotypes leading up to pregnancy recognition in cattle†.

ABSTRACT: Reproductive efficiency in livestock is a major driver of sustainable food production. The poorly understood process of ruminant conceptus elongation (a) prerequisites maternal pregnancy recognition, (b) is essential to successful pregnancy establishment, and (c) coincides with a period of significant conceptus mortality. Conceptuses at five key developmental stages between Days 8-16 were recovered and cultured in vitro for 6 h prior to conditioned media analysis by untargeted ultrahigh-performance liquid chromatography tandem mass spectroscopy. This global temporal biochemical interrogation of the ex situ bovine conceptus unearths two antithetical stage-specific metabolic phenotypes during tubular (metabolically retentive) vs. filamentous (secretory) development. Moreover, the retentive c

SUBMITTER: Simintiras CA 

PROVIDER: S-EPMC8111239 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature