Rs1840680 single nucleotide polymorphism in Pentraxin 3: a potential protective biomarker of severe community-acquired pneumonia.

ABSTRACT:

Objective

Single nucleotide polymorphisms (SNPs) of pentraxin 3 (PTX3) are associated with various outcomes of lung infections. This study aimed to analyze the relationship between PTX3 polymorphisms and the severity of community-acquired pneumonia (CAP).

Methods

This is a retrospective case-control study comprising 43 patients with severe CAP (SCAP) and 97 patients with non-severe CAP. Three SNPs in the PTX3 gene (rs2305619, rs3816527, and rs1840680) from peripheral blood samples were genotyped by real-time polymerase chain reaction. The association between each SNP and the CAP severity was analyzed by logistic regression analysis.

Results

We found that the rs1840680 polymorphism was significantly associated with CAP clinical severity. How

SUBMITTER: Zeng Q 

PROVIDER: S-EPMC8111280 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature