Inhibition-directed multimodal imaging fusion patterns in adults with ADHD and its potential underlying "gene-brain-cognition" relationship.

ABSTRACT:

Aims

Inhibition deficits have been suggested to be a core cognitive impairment in attention-deficit/hyperactivity disorder (ADHD). Exploring imaging patterns and the potential genetic components associated with inhibition deficits would definitely promote our understanding of the neuropathological mechanism of ADHD. This study aims to investigate the multimodal imaging fusion features related to inhibition deficits in adults with ADHD (aADHD) and to make an exploratory analysis of the role of inhibition-related gene, NOS1, on those brain alterations.

Methods

Specifically, multisite canonical correlation analysis with reference plus joint independent component analysis (MCCAR + jICA) was conducted to identify the joint co-varying gray matter volume (GMV) and the functional co

SUBMITTER: Guo X 

PROVIDER: S-EPMC8111492 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature