Aberrant multimodal brain networks in patients with anti-NMDA receptor encephalitis.

ABSTRACT:

Aims

To explore large-scale brain network alterations and examine their clinical and neuropsychological relevance in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.

Methods

Twenty-four patients with anti-NMDAR encephalitis and 26 matched healthy controls (HCs) were enrolled in our study. Based on the multimodal MRI dataset, individual morphological, structural, and functional brain networks were constructed and compared between the two groups at multiple levels. The associations with clinical/neuropsychological variables and the discriminant ability of significant alterations were further studied.

Results

Multimodal network analysis revealed that anti-NMDAR encephalitis mainly affected morphological and structural networks, but subtle alteration

SUBMITTER: Wang J 

PROVIDER: S-EPMC8111502 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature