Development and Validation of a RNA Binding Protein-Associated Prognostic Model for Hepatocellular Carcinoma.

ABSTRACT:

Background

Dysregulation of RNA binding proteins (RBPs) has been identified in multiple malignant tumors correlated with tumor progression and occurrence. However, the function of RBPs is not well understood in hepatocellular carcinoma (HCC).

Methods

The RNA sequence data of HCC was extracted out of the Cancer Genome Atlas (TCGA) database and different RBPs were calculated between regular and cancerous tissue. The study explored the expression and predictive value of the RBPs systemically with a series of bioinformatic analyzes.

Results

A total of 330 RBPs, including 208 up-regulated and 122 down-regulated RBPs, were classified differently. Four RBPs (MRPL54, EZH2, PPARGC1A, EIF2AK4) were defined as the forecast related hub gene and used to construct a model for predi

SUBMITTER: Wang M 

PROVIDER: S-EPMC8111555 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature