Association of a Marker of N-Acetylglucosamine With Progressive Multiple Sclerosis and Neurodegeneration.

ABSTRACT:

Importance

N-glycan branching modulates cell surface receptor availability, and its deficiency in mice promotes inflammatory demyelination, reduced myelination, and neurodegeneration. N-acetylglucosamine (GlcNAc) is a rate-limiting substrate for N-glycan branching, but, to our knowledge, endogenous serum levels in patients with multiple sclerosis (MS) are unknown.

Objective

To investigate a marker of endogenous serum GlcNAc levels in patients with MS.

Design, setting, and participants

A cross-sectional discovery study and cross-sectional confirmatory study were conducted at 2 academic MS centers in the US and Germany. The discovery study recruited 54 patients with MS from an outpatient clinic as well as 66 healthy controls between April 20, 2010, and June 21, 2013. Th

SUBMITTER: Brandt AU 

PROVIDER: S-EPMC8111565 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature