Pharmacogenetics of tenofovir and emtricitabine penetration into cerebrospinal fluid.

ABSTRACT:

Background

Blood-cerebrospinal fluid (CSF) barrier transporters affect the influx and efflux of drugs. The antiretrovirals tenofovir and emtricitabine may be substrates of blood-brain barrier (BBB) and blood-CSF barrier transporters, but data are limited regarding the pharmacogenetics and pharmacokinetics of their central nervous system (CNS) penetration.

Objectives

We investigated genetic polymorphisms associated with CSF disposition of tenofovir and emtricitabine.

Method

We collected paired plasma and CSF samples from 47 HIV-positive black South African adults who were virologically suppressed on efavirenz, tenofovir and emtricitabine. We considered 1846 single-nucleotide polymorphisms from seven relevant transporter genes (ABCC5, ABCG2, ABCB1, SLCO2B1, SCLO1A2,

SUBMITTER: Decloedt EH 

PROVIDER: S-EPMC8111650 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature