Genetic and immunologic findings in children with recurrent aphthous stomatitis with systemic inflammation.

ABSTRACT:

Background

Recurrent aphthous stomatitis with systemic signs of inflammation can be encountered in inflammatory bowel disease, Behçet's disease (BD), Systemic Lupus Erythematosus (SLE). In addition, it has been proposed that cases with very early onset in childhood can be underpinned by rare monogenic defects of immunity, which may require targeted treatments. Thus, subjects with early onset recurrent aphthous stomatitis receiving a clinical diagnosis of BD-like or SLE-like disease may deserve a further diagnostic workout, including immunologic and genetic investigations.

Objective

To investigate how an immunologic, genetic and transcriptomics assessment of interferon inflammation may improve diagnosis and care in children with recurrent aphthous stomatitis with systemic inf

SUBMITTER: Girardelli M 

PROVIDER: S-EPMC8111718 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature