Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach.

ABSTRACT:

Background

Inconsistent positivity thresholds, image analysis pipelines, and quantitative outcomes are key challenges of multisite studies using more than one β-amyloid (Aβ) radiotracer in positron emission tomography (PET). Variability related to these factors contributes to disagreement and lack of replicability in research and clinical trials. To address these problems and promote Aβ PET harmonization, we used [¹⁸F]florbetaben (FBB) and [¹⁸F]florbetapir (FBP) data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to derive (1) standardized Centiloid (CL) transformations and (2) internally consistent positivity thresholds based on separate young control samples.

Methods

We analyzed Aβ PET data using a native-space, automated image processing

SUBMITTER: Royse SK 

PROVIDER: S-EPMC8111744 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature