Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2.

ABSTRACT: SARS-CoV-2 infection is associated with lower blood oxygen levels, even in patients without hypoxia requiring hospitalization. This discordance illustrates the need for a more unifying explanation as to whether SARS-CoV-2 directly or indirectly affects erythropoiesis. Here, we show significantly enriched CD71⁺ erythroid precursors/progenitors in the blood circulation of COVID-19 patients. We found that these cells have distinctive immunosuppressive properties. In agreement, we observed a strong negative correlation between the frequency of these cells with T and B cell proportions in COVID-19 patients. The expansion of these CD71⁺ erythroid precursors/progenitors was negatively correlated with the hemoglobin levels. A subpopulation of abundant erythroid cells, CD45

SUBMITTER: Shahbaz S 

PROVIDER: S-EPMC8111797 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature