Oxidant therapy improves adipogenic differentiation of adipose-derived stem cells in human wound healing.

ABSTRACT:

Background

Adipose-derived stem cells (ASC) and adipocytes are involved in numerous physiological and pathophysiological conditions, which have been extensively described in subcutaneous and visceral fat depots over the past two decades. However, much less is known about ASC and adipocytes outside classical fat tissue depots and their necessity in tissue remodeling after injury. Therefore, we investigated the etiology of adipocytes in human granulation tissue and define their possible role wound healing.

Methods

Identification of human wound tissue adipocytes was determined by immunohistochemical staining of granulation tissue sections from patients undergoing surgical debridement. Stromal cell fractions from granulation tissue and subcutaneous fat tissue were generated by c

SUBMITTER: Ploner C 

PROVIDER: S-EPMC8111898 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature