Intracranial VCAM1 at time of mechanical thrombectomy predicts ischemic stroke severity.

ABSTRACT:

Background

Emergent large vessel occlusion (ELVO) strokes are devastating ischemic vascular events for which novel treatment options are needed. Using vascular cell adhesion molecule 1 (VCAM1) as a prototype, the objective of this study was to identify proteomic biomarkers and network signaling functions that are potential therapeutic targets for adjuvant treatment for mechanical thrombectomy.

Methods

The blood and clot thrombectomy and collaboration (BACTRAC) study is a continually enrolling tissue bank and registry from stroke patients undergoing mechanical thrombectomy. Plasma proteins from intracranial (distal to clot) and systemic arterial blood (carotid) were analyzed by Olink Proteomics for N=42 subjects. Statistical analysis of plasma proteomics used independent samp

SUBMITTER: Maglinger B 

PROVIDER: S-EPMC8111916 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature