Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery.

ABSTRACT: Leishmaniasis is a group of neglected infectious diseases, with approximately 1. 3 million new cases each year, for which the available therapies have serious limitations. Therefore, it is extremely important to apply efficient and low-cost methods capable of selecting the best therapeutic targets to speed up the development of new therapies against those diseases. Thus, we propose the use of integrated computational methods capable of evaluating the druggability of the predicted proteomes of Leishmania braziliensis and Leishmania infantum, species responsible for the different clinical manifestations of leishmaniasis in Brazil. The protein members of those proteomes were assessed based on their structural, chemical, and functional contexts applying methods that integrate dat

SUBMITTER: Dos Santos Vasconcelos CR 

PROVIDER: S-EPMC8111926 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature