Sex disparities in vitamin D status and the impact on systemic inflammation and survival in rectal cancer.

ABSTRACT:

Background

We reported previously that rectal cancer patients given curative-intent chemotherapy, radiation, and surgery for non-metastatic disease had enhanced risk of metastatic progression and death if circulating levels of 25-hydroxyvitamin D [25(OH) D] were low. Here we investigated whether the association between the vitamin D status and prognosis pertains to the general, unselected population of rectal cancer patients.

Methods

Serum 25(OH) D at the time of diagnosis was assessed in 129 patients, enrolled 2013-2017 and representing the entire range of rectal cancer stages, and analyzed with respect to season, sex, systemic inflammation, and survival.

Results

In the population-based cohort residing at latitude 60°N, 25(OH) D varied according to season in men only

SUBMITTER: Abrahamsson H 

PROVIDER: S-EPMC8111928 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature