Efficacy and tolerability of atypical antipsychotics for acute bipolar depression: a network meta-analysis.

ABSTRACT:

Background

While clinical trial evidence has firmly established the efficacy of several atypical antipsychotics (AAPs) for treating bipolar depression, no randomized controlled trials (RCT's) comparing AAPs have been conducted. This Bayesian network meta-analysis (NMA) compared the relative efficacy and tolerability of AAP monotherapy in adults with bipolar depression.

Methods

Efficacy measures included change in Montgomery Åsberg Depression Rating Scale (MADRS), Clinical Global Improvement - Bipolar Disorder (CGI-BP), response, and remission. Multiple tolerability outcomes were examined. Results from random effects models were reported as difference in change from baseline for continuous variables or odds ratios for dichotomous variables. Treatments were ranked using the su

SUBMITTER: Kadakia A 

PROVIDER: S-EPMC8112003 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature