Maternal oxycodone treatment causes pathophysiological changes in the mouse placenta.

ABSTRACT:

Introduction

Pregnant women are increasingly being prescribed and abusing opioid drugs. As the primary communication organ between mother and conceptus, the placenta may be vulnerable to opioid effects but also holds the key to better understanding how these drugs affect long-term offspring health. We hypothesized that maternal treatment with oxycodone (OXY), the primary opioid at the center of the current crisis, deleteriously affects placental structure and gene expression patterns.

Methods

Female mice were treated daily with 5 mg OXY/kg or saline solution (Control, CTL) for two weeks prior to breeding and until placenta were collected at embryonic age 12.5. A portion of the placenta was fixed for histology, and the remainder was frozen for RNA isolation followed by RNAseq

SUBMITTER: Green MT 

PROVIDER: S-EPMC8112023 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature