The Effect of Annexin A1 as a Potential New Therapeutic Target on Neuronal Damage by Activated Microglia.

ABSTRACT: Brain disease is known to cause irrevocable and fatal loss of biological function once damaged. One of various causes of its development is damage to neuron cells caused by hyperactivated microglia, which function as immune cells in brain. Among the genes expressed in microglia stimulated by various antigens, annexin A1 (ANXA1) is expressed in the early phase of the inflammatory response and plays an important role in controlling the immune response. In this study, we assessed whether ANXA1 can be a therapeutic target gene for the initial reduction of the immune response induced by microglia to minimize neuronal damage. To address this, mouse-origin microglial cells were stimulated to mimic an immune response by lipopolysaccharide (LPS) treatment. The LPS treatment caused activation of ANX

SUBMITTER: You JE 

PROVIDER: S-EPMC8112165 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature