Frontal theta and beta oscillations during lower-limb movement in Parkinson's disease.

ABSTRACT:

Objectives

Patients with Parkinson's disease (PD) have deficits in lower-limb functions such as gait, which involves both cognitive and motor dysfunction. In PD, theta and beta brain rhythms are associated with cognitive and motor functions, respectively. We tested the hypothesis that PD patients with lower-limb abnormalities would exhibit abnormal theta and beta rhythms in the mid-frontal cortical region during lower-limb action.

Methods

This study included thirty-nine participants; 13 PD patients with FOG (PDFOG+), 13 without FOG (PDFOG-), and 13 demographically-matched controls. We recorded scalp electroencephalograms (EEG) during a lower-limb pedaling motor task, which required intentional initiation and stopping of a motor movement.

Results

FOG scores were correl

SUBMITTER: Singh A 

PROVIDER: S-EPMC8112379 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature