Effectiveness and safety of glibenclamide for stroke: protocol for a systematic review and meta-analysis.

ABSTRACT:

Introduction

Despite the continuous improvement in modern medical treatment, stroke is still a leading cause of death and disability worldwide. How to effectively improve the survival rate and reduce disability in patients who had a stroke has become the focus of many investigations. Recent findings concerning the benefits of glibenclamide as a neuroprotective drug have initiated a new area for prospective studies on the effects of sulfonylureas. Given the high mortality and disability associated with stroke, it is essential to weigh the benefits of neuroprotective drugs against their safety. Therefore, the objective of the current study is to conduct a systematic review using meta-analysis to assess the benefits and safety of glibenclamide as a neuroprotective drug.

Methods and

SUBMITTER: Wen L 

PROVIDER: S-EPMC8112404 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature