Fracture mechanics analysis of fibrin fibers using mesoscale and continuum level methods.

ABSTRACT: Computational models for simulating and predicting fibrin fiber fracture are important tools for studying bulk mechanical properties and mechanobiological response of fibrin networks in physiological conditions. In this work, we employed a new strategy to model the mechanical response of a single fibrin fiber using a collection of bundled protofibrils and modeled the time-dependent properties using discrete particle simulations. Using a systematic characterization of the parameters, this model can be used to mimic the elastic behavior of fibrin fibers accurately and also to simulate fibrin fiber fracture. In addition, a continuum model was modified and used to obtain the individual fibrin fiber fracture toughness properties. Using this model and the experimentally available fibrin mechanic

SUBMITTER: Yesudasan S 

PROVIDER: S-EPMC8112576 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature