Sequencing chemotherapy before radiotherapy for women with stage IIIC endometrial cancer.

ABSTRACT:

Objective

It is unclear how to best sequence adjuvant chemotherapy and radiotherapy for advanced endometrial cancer. We studied the outcomes for women treated with chemotherapy before radiotherapy in a chemotherapy-first (chemotherapy for 6 cycles followed radiotherapy) or 'sandwich' approach (chemotherapy for 3 cycles followed by radiotherapy and subsequently chemotherapy for 3 cycles).

Methods

Women with stage IIIC endometrial cancer and no gross residual disease treated with chemotherapy before radiotherapy between April 2003 and April 2016 were included. The Kaplan-Meier method was used to estimate recurrence and survival. We performed a meta-analysis of endometrial cancer trials comparing chemotherapy and radiotherapy versus radiotherapy alone.

Results

A total of

SUBMITTER: Narasimhulu DM 

PROVIDER: S-EPMC8112578 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature